Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Canada Likely to Miss WHO’s Hepatitis C Elimination Target, Research Shows

April 17, 2024

[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

Loss of SREBP-1c Ameliorates Iron-Induced Liver Fibrosis by Decreasing Lipocalin-2

April 17, 2024

[Experimental & Molecular Medicine] Scientists examined the role of sterol regulatory element-binding protein (SREBP)-1c in nonalcoholic steatohepatitis (NASH) and the regulation of lipocalin-2 (LCN2) gene expression. Wild-type and SREBP-1c knockout mice were fed a high-fat/high-sucrose diet, treated with carbon tetrachloride, and subjected to LCN2 overexpression.

A Spatiotemporal Atlas of Mouse Liver Homeostasis and Regeneration

April 17, 2024

[Nature Genetics] This integrative study dissected in detail the molecular gradients controlling liver cell function, systematically defining how gene networks were dynamically modulated through intercellular communication to promote regeneration.

Phenotypes of MASLD-Associated Hepatocellular Carcinoma

April 12, 2024

[Clinical Gastroenterology And Hepatology] Metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis, has emerged as the most common chronic liver disease worldwide and a leading cause of HCC.

Blue Faery Awards Liver Cancer Research Grant

April 12, 2024

[Blue Faery (PR Newswire, Inc.)] Blue Faery: The Adrienne Wilson Liver Cancer Association announced the annual Blue Faery Award (BFA) for Excellence in Liver Cancer Research. Primary liver cancer, also known as HCC, is the third leading cause of cancer deaths worldwide. Blue Faery created the award to recognize medical professionals who do innovative HCC research.

‘Mini Liver’ Will Grow in Person’s Own Lymph Node in Bold New Trial

April 11, 2024

[Nature] A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.

Diagnostic Performance of PIVKA-II in Identifying Recurrent Hepatocellular Carcinoma following Curative Resection: A Retrospective Cohort Study

April 10, 2024

[Scientific Reports] A multicenter, retrospective, and observational study was conducted. During the overall follow-up of five years, HCC patients who had curative resection were monitored every three months in the first year post-surgery and every six months thereafter if no recurrence occurred.

cGAS Suppresses Hepatocellular Carcinoma Independent of Its cGAMP Synthase Activity

April 10, 2024

[Cell Death & Differentiation] The authors revealed that Cyclic GMP–AMP synthase (cGAS) was significantly downregulated in clinical HCC tissues, and its dysregulation contributed to the progression of HCC.

Eureka Therapeutics Announces UCSF Benioff Children’s Hospitals as First California Site for ARYA-2 Clinical Trial Targeting Pediatric Liver Cancers

April 9, 2024

[Eureka Therapeutics, Inc.] Eureka Therapeutics, Inc., a clinical-stage biotechnology company developing novel T cell therapies to treat cancer, announced the activation of UCSF Benioff Children’s Hospitals as the first California site to join the ARYA-2 clinical trial.

Hepatocyte Regeneration Is Driven by Embryo-Like DNA Methylation Reprogramming

April 9, 2024

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By following the early stages of this process, investigators observed dramatic programmed changes in the DNA methylation profile, characterized by both de novo and demethylation events, with a subsequent return to the original adult pattern as the liver matures.

Proteomic Analysis of DEN and CCl4-Induced Hepatocellular Carcinoma Mouse Model

April 8, 2024

[Scientific Reports] Scientists performed proteomic analysis of this model to elucidate its proteomic characteristics. Compared with normal liver tissues, 432 differentially expressed proteins were identified in tumor tissues, among which 365 were up-regulated and 67 were down-regulated.

17β-Estradiol Protects Female Rats from Bilateral Oophorectomy-Induced Nonalcoholic Fatty Liver Disease Induced by Improving Linoleic Acid Metabolism Alteration and Gut Microbiota Disturbance

April 8, 2024

[Heliyon] The combination of liver transcriptomics and metabolomics analysis revealed that linoleic acid (LA) metabolism, a pivotal pathway in fatty acids metabolism was mainly manipulated during the induction and treatment of nonalcoholic fatty liver disease.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!