Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

ADAR2 Deficiency Ameliorates Non-Alcoholic Fatty Liver Disease and Muscle Atrophy through Modulating Serum Amyloid A1

[Journal Of Cachexia Sarcopenia And Muscle] ADAR2+/+/GluR-BR/R mice and ADAR2−/−/GluR-BR/R mice were subjected to feeding with standard chow or high-fat diet for 20 weeks at the age of 5 weeks.

Parenteral Nutrition Emulsion Inhibits CYP3A4 in an iPSC Derived Liver Organoids Testing Platform

[Journal Of Pediatric Gastroenterology And Nutrition] Investigators exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for parenteral nutriion associated liver disease. Liver organoids mimic the developing liver and contain the different hepatic cell types.

Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids

[Journal Of Proteome Research] Hepatocyte-like organoids from multidrug resistance 2 (MDR2)-deficient mice (MDR2KO) were used to study the molecular alterations caused by the deficiency of this transporter. Proteomic analysis by mass spectrometry allowed the characterization of 279 proteins that were differentially expressed in MDR2KO compared with wild-type organoids.

Prognosis and Chemotherapy Drug Sensitivity in Liver Hepatocellular Carcinoma Through a Disulfidptosis-Related lncRNA Signature

[Scientific Reports] The authors acquired transcriptomic data, corresponding clinical data, and tumor mutation data of HCC from the TCGA database. Disulfidptosis-related (DRLs) lncRNAs were determined through correlation analysis. Then, a prognostic model containing six DRLs was created by adopting univariate Cox regression, LASSO algorithm and multivariate Cox regression analysis.

Cancer Cell Genetics Shaping of the Tumor Microenvironment Reveals Myeloid Cell-Centric Exploitable Vulnerabilities in Hepatocellular Carcinoma

[Nature Communications] In newly generated, clinically-relevant somatic female HCC mouse models, investigators identified cancer genetics’ specific and stage-dependent alterations of the liver tumor microenvironment associated with distinct histopathological and malignant HCC features.

Single-Cell and Spatial Analyses Revealed the Co-Location of Cancer Stem Cells and SPP1+ Macrophage in Hypoxic Region That Determines the Poor Prognosis in Hepatocellular...

[NPJ Precision Oncology] The authors undertook a comprehensive study combining single-cell data and spatial data to obtain CSC signature and uncover its spatial structure.

Acetyl-CoA Synthetase 2 Contributes to a Better Prognosis for Liver Cancer by Switching Acetate-Glucose Metabolism

[Experimental & Molecular Medicine] Investigators elucidated the underlying mechanisms of ACSS2 in liver cancer and acetate metabolism, the relationships between patient acetate uptake and metabolic characteristics and between ACSS2 and tumor malignancies were comprehensively studied in vitro, in vivo and in humans.

SUMOylation Controls Hu Antigen R Posttranscriptional Activity in Liver Cancer

[Cell Reports] Researchers showed that Hu antigen R was SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease.

Alleviation of Taurine on Liver Injury of Type 2 Diabetic Rats by Improving Antioxidant and Anti-Inflammatory Capacity

[Heliyon] A high-fat diet and intraperitoneal injection of streptozotocin was used to induce liver injury in type 2 diabetes mellitus rats, and taurine was given as a treatment. Through the use of HE staining on paraffin sections, ELISA, and qRT-PCR, the effects of taurine on liver pathological alterations, antioxidant capacity, and inflammatory response were investigated.

Performance of ATT and UDFF in the Diagnosis of Non-Alcoholic Fatty Liver: An Animal Experiment

[Heliyon] Scientists established a Bama minipigs model with Non-Alcoholic Fatty Liver (NAFL) induced by a high-fat diet and investigate the application of attenuation coefficient and ultrasound-derived fat fraction in the diagnosis of NAFL.

First Pig Liver Transplanted Into a Person Lasts for 10 Days

[Nature News] In a milestone for the transplantation of animal organs into people, a 50-year-old clinically dead man in China has become the first person to receive a liver from a pig. With consent from the man’s family, researchers stitched the organ, from a genetically engineered miniature pig, to the man’s blood vessels, where it remained for ten days.

Advanced Liver Fibrosis Is Associated with Decreased Gait Speed in Older Patients with Chronic Liver Disease

[Scientific Reports] The authors investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

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