Volume 4.23 | June 26

2020-06-26 | HCN 4.23
Hepatic Cell News by STEMCELL Technologies
Vol. 4.23 – 26 June, 2020
TOP STORY

An Endoplasmic Reticulum Stress‐MicroRNA‐26a Feedback Circuit in Nonalcoholic Fatty Liver Disease

Scientists identified a negative feedback loop comprising hepatic endoplasmic reticulum (ER) stress and micro RNA (miRNA)‐26a in nonalcoholic fatty liver disease pathogenesis. Combining miRNA dot blot array and quantitative PCR, they found that miR‐26a was specifically induced by ER stress in liver cells.
[Hepatology]

Abstract

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The miR-92a-2-5p in Exosomes from Macrophages Increases Liver Cancer Cells Invasion via Altering the Ar/Phlpp/P-Akt/β-Catenin Signaling

Mechanism dissection revealed that miR-92a-2-5p from the exosomes could target the 3′UTR of androgen receptor (AR) mRNA to suppress AR translation, altering the PHLPP/p-AKT/β-catenin signaling to increase liver cancer cells invasion.
[Cell Death & Differentiation]

Abstract

Regulation of Hepatic Differentiation of Human Embryonic Stem Cells by Calcium Silicate Extracts for Liver Injury Repairing

The roles of calcium silicate (CS)-activated H9 cells in liver injury repair were tested by cell tracking and immunohistochemical staining. Results indicated that high concentrations of CS extracts initially enhanced definitive endodermal (DE) lineage, followed by gradual DE differentiation at low CS concentrations.
[Applied Materials Today]

Abstract

The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease

Treatment with either of two bone morphogenetic protein (BMP) inhibitors reduced hepatic triglyceride content in diabetic mice. BMP inhibitor-induced decrease in hepatic triglyceride levels were associated with decreased mRNA encoding Dgat2, an enzyme integral to triglyceride synthesis.
[Scientific Reports]

Full Article

Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Mutation of the hepatocyte nuclear factor (HNF)-1 binding site significantly decreased the promoter activity in hepatocytes, and the promoter carrying the mutated HNF-1 site was not transactivated by co-transfection of HNF-1 in a non-hepatic cell line.
[Scientific Reports]

Full Article

IFN-α-2b Induces Apoptosis by Decreasing Cellular Cholesterol Levels in Rat Preneoplastic Hepatocytes

Using in vitro and in vivo approaches, the authors evaluated apoptosis and lipid metabolism. IFN-α-2b induced changes in hepatic cholesterol mass due to decreased synthesis and increased secretion.
[Cytokine]

AbstractGraphical Abstract

Study on the Relationship between Hepatic Fibrosis and Epithelial-Mesenchymal Transition in Intrahepatic Cells

Researchers explored the relationship between the relevant regulatory factors and the epithelial-mesenchymal transition signaling pathways in the various intrahepatic cells.
[Biomedicine & PharmacoTherapy]

Full ArticleGraphical Abstract

Combination of Luteolin and Lycopene Effectively Protect against the “Two-Hit” in NAFLD through Sirt1/AMPK Signal Pathway

Scientists found that luteolin (20 μM) + lycopene (10 μM) was the best therapeutic combination in sodium palmitate (PA)-induced HepG2 cells, and significantly improved cell viability and lipid accumulation in PA-induced HepG2 cells and primary hepatocytes.
[Life Sciences]

Abstract

PD173074 Blocks G1/S Transition via CUL3-Mediated Ubiquitin Protease in HepG2 and Hep3B Cells

Researchers found fibroblast growth factor receptor 4 (FGFR4) was overexpressed in hepatocellular carcinoma cell lines HepG2 and Hep3B. They used PD173074, an FGFR4 inhibitor, to explore the role of FGFR4 and its underlying mechanism in these cell lines.
[PLoS One]

Full Article

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REVIEWS

Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Scientists give an overview of T cell receptors identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field.
[Cells]

Full Article

The Role of MDM2–p53 Axis Dysfunction in the Hepatocellular Carcinoma Transformation

The authors focus on the current studies of the MDM2–p53 axis in hepatocellular carcinoma, and specifically discuss the impact of MDM2–p53 axis dysfunction by viral infection and metabolic disease in the transformation of normal hepatocytes into hepatoma cells.
[Cell Death Discovery]

Full Article

INDUSTRY AND POLICY NEWS

Assembly Biosciences Initiates Phase II Trial Evaluating Second-Generation Core Inhibitor ABI-H2158 for Chronic Hepatitis B Infection

Assembly Biosciences, Inc. have announced the initiation of a Phase II trial of their potent, second-generation core inhibitor, ABI-H2158, for patients with HBeAg positive chronic hepatitis B infection without cirrhosis.
[Assembly Biosciences, Inc.]

Press Release

Celsion Affirms July Timing for Second Interim Analysis of the Phase III OPTIMA Study of ThermoDox® in Primary Liver Cancer

Celsion Corporation have affirmed that the independent data monitoring mommittee is scheduled to meet during the first half of July to conduct the second pre-planned interim safety and efficacy analysis of the Phase III OPTIMA Study with ThermoDox® plus radiofrequency ablation in patients with hepatocellular carcinoma, or primary liver cancer.
[Celsion Corp.]

Press Release

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behaviour, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Editorial

FEATURED EVENT

2020 Parenteral Drug Association (PDA) Annual Meeting

July 20 – July 22
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JOB OPPORTUNITIES

Oligonucleotide Chemist – Liver and CNS

Deep Genomics – Toronto, Ontario, Canada

Post Doctoral Scholarship – Molecular Metabolism

University of Gothenburg – Gothenburg, Sweden

Postdoctoral Research Scientist – Liver Diseases

Columbia University Medical Center – New York, New York, United States

Postdoctoral Scientist – Gene Editing in Liver Disease

Beam Therapeutics – Cambridge, Massachusetts, United States

Associate Professor – Hepatology

Yale University – New Haven, Connecticut, United States

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