Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Bioreactor-Based Stem Cell Therapy for Liver Fibrosis

[Biofabrication] 5% liver fibrosis serum was used to induce the therapeutic phenotype of MSCs, and a fluid bioreactor carrying a co-culture system of hepatocytes and MSCs was constructed to produce the therapeutic medium.

Applying Machine Learning for Multi-Individual Raman Spectroscopic Data to Identify Different Stages of Proliferating Human Hepatocytes

[iScience] Scientists developed a machine learning framework to integrate single-cell Raman spectroscopy from multiple donors and identify different stages of ProliHHs. A repository of more than 14,000 Raman spectra, consisting of primary human hepatocytes (PHHs) and different passages of ProliHHs from six donors, was generated.

First-in-Class MKK4 Inhibitors Enhance Liver Regeneration and Prevent Liver Failure

[Cell] Investigators reported on the structure-based development and characterization of first-in-class small molecule inhibitors of the dual-specificity kinase MKK4.

Hepatic Nutrient and Hormone Signaling to mTORC1 Instructs the Postnatal Metabolic Zonation of the Liver

[Nature Communications] Researchers showed that simultaneous genetic activation of nutrient and hormone signaling to mTORC1 in hepatocytes resulted in impaired establishment of postnatal metabolic and zonal identity of hepatocytes.

Bio-Responsive Au-miR-183 Inhibitor Enhances Immunotherapy in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death

[Journal Of Controlled Release] Scientists constructed a bio-responsive Au-miR-183 inhibitor delivery system targeting liver cancer stem cells, and adopted the strategy of combining αPD-L1 immunotherapy.

Construction of In Vitro Liver-on-a-Chip Models and Application Progress

[Biomedical Engineering OnLine] Invesigators discuss the development of liver-on-a-chip and its research progress in liver diseases, hepatotoxicity tests, and drug screening, as well as chip combinations.

A Programmed Cell Death-Related Gene Signature to Predict Prognosis and Therapeutic Responses in Liver Hepatocellular Carcinoma

[Discover Oncology] Consensus clustering analysis was performed to subtype HCC patients in The Cancer Genome Atlas database. Differentially expressed genes among the subtypes were filtered and subjected to the least absolute shrinkage and selection operator regression analysis and univariate Cox regression analysis to filter prognostic genes.

UChicago Medicine Among the First to Offer Histotripsy for Liver Tumors

[OncLive] The University of Chicago Medicine was the first health system in Illinois to treat patients with histotripsy, a new noninvasive technology that uses ultrasound energy to precisely destroy liver tumors.

Plasma Extracellular Vesicle MicroRNAs Reflecting the Therapeutic Effect of the CBP/β-Catenin Inhibitor PRI-724 in Patients with Liver Cirrhosis

[Scientific Reports] Scientists investigated whether the profiles of circulating microRNAs packaged in extracellular vesicles were associated with responses to liver fibrosis treatments.

US FDA Approves First Drug for Fatty Liver Disease NASH

[Reuters] The US FDA has approved Madrigal Pharmaceuticals' drug for a fatty liver disease known as non-alcoholic steatohepatitis (NASH), the first treatment to get the nod for the condition and opening up a multi-billion dollar opportunity.

Hepatic Danger Signaling Triggers TREM2+ Macrophage Induction and Drives Steatohepatitis via MS4A7-Dependent Inflammasome Activation

[Science Translational Medicine] The authors identified membrane-spanning 4-domains a7 (MS4A7) as a NAM-specific pathogenic factor that exacerbated MASH progression in mice.

Cell Senescence in Liver Diseases: Pathological Mechanism and Theranostic Opportunity

[Nature Reviews Gastroenterology & Hepatology] The authors provide an updated description of the pathophysiological events in which hepatic senescent cells are involved and their role in liver disease progression.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

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