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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
DCDC2 Inhibits Hepatic Stellate Cell Activation and Ameliorates CCl4-Induced Liver Fibrosis by Suppressing Wnt/β-Catenin Signaling
[Scientific Reports] Investigators elucidated the role of doublecortin domain containing 2 (DCDC2) in liver fibrosis. Their findings revealed a reduction in DCDC2 expression in both human fibrotic liver tissues and carbon tetrachloride (CCl4)-induced mouse liver fibrotic tissues.
LAGE3 Promotes Angiogenesis on Hepatocellular Carcinoma by Stabilizing VEGFA mRNA
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Increased expression of LAGE3 cloud led to upregulated VEGFA secretion and angiogenesis in hepatocellular carcinoma. The mechanistic study revealed LAGE3 was required for the VEGFA mRNA stability.
A Novel Engineered IL-21 Receptor Arms T-Cell Receptor-Engineered T Cells (TCR-T Cells) Against Hepatocellular Carcinoma
[Signal Transduction And Targeted Therapy] Researchers determined the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell therapy.
Long-Term Risks of Cirrhosis and Hepatocellular Carcinoma across Steatotic Liver Disease Subtypes
[American Journal Of Gastroenterology] The authors enrolled 332,175 adults who participated in a health screening program between 1997 and 2013. Participants were categorized into various subtypes, including metabolic dysfunction-associated SLD (MASLD), MASLD with excessive alcohol consumption , and alcohol-related liver disease, based on ultrasonography findings, alcohol consumption patterns, and cardiometabolic risk factors.
Hepatic Signal Transducer and Activator of Transcription-3 signaling Drives Early-Stage Pancreatic Cancer Cachexia via Suppressed Ketogenesis
[Journal Of Cachexia Sarcopenia And Muscle] Researchers establishes a direct link between skeletal muscle homeostasis and hepatic metabolism. Dietary and anti-inflammatory interventions that restored ketogenesis may be a viable preventative approach for pre-cachectic patients with pancreatic cancer.
Monitoring Hepatocellular Carcinoma Using Tumor Content in Circulating Cell-Free DNA
[Clinical Cancer Research] Scientists evaluated the utility of tumor content in circulating cell-free DNA for monitoring HCC throughout its natural history. They included 67 hepatitis B virus-related HCC patients, of whom 17 had paired pre- and post-treatment samples, and 90 controls.
Notch1 Regulates Hepatic Thrombopoietin Production
[Blood] Investigators noted thrombocytopenia in mice with hepatic Notch1 deficiency, and so investigated thrombopoietin production and other features of platelets in mice. They found that the liver ultrastructure and hepatocyte function were comparable between control mice and Notch1-deficient mice.
ER Stress Signaling at the Interphase Between MASH and Hepatocellular Carcinoma
[Hepatology] The authors propose that chronic endoplasmic reticulum stress is a common transversal factor contributing to the transition from liver disease to HCC. Interventional strategies to target the unfolded protein response in HCC as cancer therapy are also discussed.
Viral Hepatitis Is a Silent Killer. It Can’t Be Eliminated If It Isn’t Tracked
[Stat] By all accounts, the US should be able to eliminate viral hepatitis, but instead new cases are on the rise, largely due to the opioid epidemic and increasing viral hepatitis transmission through injection drug use.
Canada Likely to Miss WHO’s Hepatitis C Elimination Target, Research Shows
[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.
Loss of SREBP-1c Ameliorates Iron-Induced Liver Fibrosis by Decreasing Lipocalin-2
[Experimental & Molecular Medicine] Scientists examined the role of sterol regulatory element-binding protein (SREBP)-1c in nonalcoholic steatohepatitis (NASH) and the regulation of lipocalin-2 (LCN2) gene expression. Wild-type and SREBP-1c knockout mice were fed a high-fat/high-sucrose diet, treated with carbon tetrachloride, and subjected to LCN2 overexpression.
A Spatiotemporal Atlas of Mouse Liver Homeostasis and Regeneration
[Nature Genetics] This integrative study dissected in detail the molecular gradients controlling liver cell function, systematically defining how gene networks were dynamically modulated through intercellular communication to promote regeneration.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
